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重组人生长激素对COPD营养不良患者胰岛素抵抗影响的临床研究 被引量:2

Clinical Research of rhGH Influence on the Insulin Resistentence of COPD Patients with Malnutritional
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摘要 目的:观察重组人生长激素(rhGH)对慢性阻塞性肺疾病(COPD)营养不良患者胰岛素抵抗(IR)的影响。方法:60例COPD营养不良的患者随机分治疗组和对照组,两组均给予抗感染、氧疗及营养支持治疗等,治疗组在上述治疗基础上加用rhGH,每天皮下注射rhGH(0.1μ/kg.d)连用7-10日,而对照组给予等量的注射用水。治疗前后分别测空腹血糖、空腹胰岛素,并计算两组治疗后胰岛素敏感指数(ISI)。结果:治疗前血糖、胰岛素及ISI组间比较差异无统计学意义(P〉0.05),而治疗后均有统计学意义(P〈0.05);治疗组血糖在治疗后较治疗前升高,差异有统计学意义(P〈0.05),而对照组则降低,差异无统计学意义(P〉0.05)。结论:rhGH治疗COPD营养不良患者会引起血糖升高,胰岛素抵抗。 Objective: To investigate the influence of recombinant human growth hormone (rhGH) treating on Insulin resistentance of chronic obstructive pulmonary disease (COPD) patients with malnutrition. Methods: 60 COPD patients were randomly selected to treatment group and control group. All patients were treated with antibiotic ,oxygen therapy and allowance of nutrients. In every, evening for 7 - 10 days, fhGH and aqua pro injection were injected subcutaneously(0.1u/Kg · d)to the patients of treatment group and control, group respectively. Blood sugar aod insulin were surveyed before and after the treatment,and insulin sensitive index (ISI) was calculated. Results: Before injection, the difference of blood sugar,insulin and ISI between the two groups was not significant( P 〉 0.05 ) , but on the contrary after treatmeut( P 〈 0.05 ). After treatment, blood sugar of treatment group advanced ( P 〈 0.05 ) , but depressed to the other group( P 〉 0.05 ). Conclusion : The treatment of rhGH on COPD patients with malnutrition induced insulin resistance and the increaeement of blood sugar .
出处 《赣南医学院学报》 2009年第1期12-13,共2页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 重组人生长激素 慢性阻塞性肺疾病 胰岛素抵抗 Recombinant human growth hormone Chronic obstructive pulmonary disease insulin resistance
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