糊精纳米粒包载阿司匹林的研究

Study of dextrin nanoparticles as a micro-carrier for aspirin

以糊精为原料,经糊化形成多糖后,用三偏磷酸钠为交联剂,Span60与Tween60为乳化剂,正戊醇为助表面活性剂,正己烷为油相,阿司匹林为载用药物,采用反相微乳液法制备载药糊精粒子。以载药量为指标进行单因素及正交试验,得到载药糊精粒子的较佳制备条件为:交联剂用量0.012 g,正戊醇用量16 mL,油相与水相体积比100∶25,投药量70 mg,糊精液质量分数2%,平均粒径为320 nm。对优化条件下制备的粒子进行缓释实验,体外释药50%需9 h,具有较好的缓释性能。

Aspirin- carried dextrin nanoparticles were prepared. The polysaccharides obtained by gelatinizing dextrin were used as basic material. The nanoparticles were prepared by inverse emulsion method with sodium trimetaphosphate as cross -linking agent, Span60 and Tween60 as surface active agent, 1 -amyl alcohol as co - surfactant and n - hexane as the oil phase, and aspirin as the drug. Through monofactorial and orthogonal experiments with drug carrying capacity as the index, the optimum conditions for making aspirin -carried dextrin nanoparticles of 320 nm in diameter were found as following ： 0. 012 g cross - linking agent, 16 mL 1 - amyl alcohol, 100/25 （V/V） Span60/Tween60 , 70 mg aspirin, 2% （ w ） dextrin. 50% of aspirin could be released from the nanoparticles in vitro in 9 h.