不同剂量的雷公藤多苷片在预防过敏性紫癜肾损害方面的疗效比较

Comparison of Efficacies on Prevention from Renal Damage of Henoch-Schonlein Purpura Treated with Tripterygium Wilfordii Polyglycoside Tablets of Different Doses

目的探讨不同剂量的雷公藤多苷片在预防过敏性紫癜肾损害方面的临床疗效。方法将66例过敏性紫癜患儿随机分为对照组、低剂量组及高剂量组,每组各22例。对照组仅采用常规治疗;低剂量组和高剂量组均在常规治疗基础上分别加用雷公藤多苷片1mg·kg-1.d-1和1.5mg·kg-1.d-1。观察各组患儿尿微量白蛋白(尿ALB)和尿N-乙酰-β-D氨基葡萄糖苷酶(尿NAG酶)指标情况。结果三组患儿治疗后尿ALB和尿NAG酶与本组治疗前比较有显著性差异(P<0.05);治疗后2个月后,低剂量组与高剂量组尿ALB与尿NAG酶情况均显著低于对照组,且高剂量组亦显著低于低剂量组,三组比较有显著性差异(P<0.05)。结论雷公藤多苷片可有效预防过敏性紫癜肾损害的发生,且高剂量雷公藤多苷片疗效优于低剂量组,具有临床应用价值。

Objective To explore clinical efficacy on prevention from renal damage of henoch-schonlein purpura（HSP）treated with Tripterygium Wilfordii Polyglycoside Tablets（TWP）of different doses.Methods 66 cases of HSP in children were divided randomly into control group,low-dose group and high-dose group,22 cases in each one.In control group,routine treatment was applied.In low-dose group and high-dose group,TWP 1 mg/kg/d and 1.5 mg/kg/d was administered respectively.It was to observe microalbumiuria（urine ALB）and urine β-N-acetyl-D-glucosaminidase（urine NAG）.Results Significant differences were presented in urine ALB and NAG before and after treatment of each group（P〈0.05）.2 months after treatment,the outcomes of urine ALB and NAG in low-dose and high-dose groups were lower significantly than those in control group,and the outcomes in high-dose group were lower significantly than those in low-dose group.Significant difference was discovered in comparison of three groups（P〈0.05）.Conclusion TWP prevents from renal damage of henoch-schonlein purpura.The efficacy of high-dose TWP is superior to that of low-dose one.Hence the therapy is worthy to be applied clinically.