持续小剂量口服他达拉非治疗ED的疗效观察

Clinical efficacy of long term oral low dose of tadalafil on treatment of ED

目的评估持续口服小剂量他达拉非治疗ED的疗效。方法124例ED患者随机分为两组:希爱力(他达拉非商品名)组和复方玄驹组,分别接受为期3个月的治疗,治疗后各组随访6个月。在治疗前后及随访6个月后记录各组患者IIEF-5评分及患者性生活日记中插入和保持勃起的成功率并比较研究。结果治疗前2组患者IIEF-5评分分别为(10.26±4.35)分、(10.38±3.42)分,差异无统计学意义(P>0.05)。治疗后IIEF-5评分分别为(20.46±3.05)分、(15.58±4.32)分:随访6个月后IIEF-5评分分别为(18.46±2.47)分、(11.5 8±3.15)分,差异均有统计学意义(P<0.01)。治疗后及随访后两组间差异有统计学意义(P<0.05)。药物治疗后,患者日记中插入和保持勃起的成功率大幅度增高,希爱力组优于复方玄驹组。结论在治疗ED疗效方面,持续口服小剂量他达拉非优于中成药复方玄驹,可作为治疗ED的一线用药。

Objective To evaluate the efficacy of long term oral low dose of tadalafil on treatment of erectile dysfunction（ED）. Methods Total of 124 ED patients were divided into two groups randomly including Ciails group and FuFang XuanJu group. IIEF-5 scrores of patients in each group were recorded and compared before and after 3-months treatment and 6-months after discontinuing the drug and the satisfaction degree of coitus in patients diary were also compara- tively analyzed. Results Before treatment, the IIEF-5 scores of two groups were 10.26±4.35 and 10.38±3.42 respectively and no significant difference was found between two groups （P〉0.05）. After treatment, the IIEF-5 scores were 20.46±3. 05 and 15.58±4.82 respectively,and 6-months after discontinuing the drug, the IIEF-5 scores were 18.46±2.47 and 11.58±3.15 respectively. There was a significant difference between pre-treatment and post-treatment（P〈0. 01）. A significant difference in IIEF-5 scores was also found in two groups post treatment and 6-months after discontinuing the drug, （P〈0.05）. Tadalafil was shown to be better in improving satisfaction degree of coitus than. Conclusion For treatment of ED, clinical efficiacy of continuous low dose oftadalafil was superior to that of FuFang XuanJu and should be recommended to be a better option in therapy of ED.