O/W型微乳法制备纳米植物甾醇酯

Preparation of Nano-plant Sterol Ester by Oil-in-water Micro Emulsion Method

[目的]探讨O／W微乳法制备纳米植物甾醇酯的效果。[方法]选择适当的乳化剂和乳化温度以及水和乳化剂的质量比，根据表面活性剂不同的HLB值进行复配，采用O/W微乳法制备纳米植物甾醇酯纳米乳液。[结果]选择蔗糖脂肪酸酯（HLB11）与蔗糖脂肪酸酯（HLB16）和三聚甘油单硬脂酸酯（HLB7．5）进行复配，体系的HLB值≥13．0，复配的3种表面活性剂可以完全溶解于水性材料中，在水：丙三醇为1：1、乳化温度为60℃和pH值为6．0的条件下，形成的乳液最稳定。用O／W微乳液法制备的植物甾醇酯颗粒分布在200～300am，且分布均匀，分布集中在263．9nm，放置后稳定，无漂浮和沉降。[结论]该研究为功能材料的生产奠定了基础。

[ Objective ] The aim was to discuss the effect of preparing nano-plant sterol ester by oil-in-water micro emulsion method. [ Method] The proper emulsifier, emulsification temperature and the mass ratio of water and emulsifier were selected, the complex formulation was done according to different HLB values of surfactants and the nano-emulsion of nanosize plant sterol ester was prepared by oil-in-water micro emulsion method. [ Result] When selecting HLB 11 to make complex formulation with HLB 16 and HLB 7.5, the HLB value of the system was no less than 13.0, and the 3 kinds of surfactants for complex formulation could be dissolved in the water-soluble materials completely. When the water-glycerol ratio was 1 to 1, emulsification temperature was 60 ℃ and pH value was 6.0, the formed emulsion was most stable. The plant sterol ester particles prepared by oil-in-water micro emulsion method distributed in 200 - 300 nm and the distribution was even and focused on 263.9 nm. After deposition, the emulsion was stable and had no float and sedimentation appeared. [ Conclusion ] The research laid the foundation for the production of functional materials.