高血压肾病尿α_1-MG等五种蛋白放免法检测的应用价值

Clinical significance of urinary microproteins determination in patients with hyperteensive real disease

本文采用放射免疫法（RIA）对50例正常人及144例高血压（EH）患者尿α1－MG、β2－MG、THP、Alb及IgG五种微量蛋白排泄水平进行测定。结果显示：尿α1－MG在Ⅰ期EH时就有明显改变（P＜0．01）。随病程的进展，尿THP排泄水平逐渐下降；其他指标均逐渐上升。尿五种蛋白联合RIA可较早反映高血压患者肾功能损害，其方法灵敏，无损伤，可作为肾功能检测的常规手段。

Urine α1-MG.β2-MG.THPAlb and IgG were determined in 50 healty subjects and 114 patients with essential hypertension (EH)by using RIA.A correlation analysis of urine serial microprotein levels with theendogonous creatinine clearance rate(CCr)was explorated.The results showed that in early EH patientsα1-MG level was changed obviously (P<0.01). Urine levels of α1-MG.β2-MG.THP.Alb and IgG werechanged obviously followed the progression of disease.Urine micrproteins determination may early reflectthe impairment of renal function.