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血清sCD_(44v6)检测在肺癌中的临床意义

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摘要 目的探讨血清可溶性CD_(44v6)(sCD_(44v6))检测在肺癌的诊断和治疗中的临床意义。方法对75例肺癌患者和30名正常健康者(正常组)的血清标本,采用ELISA定量法检测sCD_(44v6)含量。结果肺癌患者血清sCD_(44v6)含量为(314.77±84.83)ng/ml,显著高于正常组(101.10±9.18)ng/ml(P<0.000)。肺癌患者根治术后血清sCD_(44v6)较术前明显下降(P<0.000);化疗后血清sCD_(44v6)较化疗前明显下降(P<0.000)。早期(Ⅰ期+Ⅱ期)肺癌患者血清sCD_(44v6)显著低于晚期(Ⅲ期+Ⅳ期)患者(P<0.01)。不同组织类型的肺癌患者血清sCD_(44v6)含量差异无统计学意义(P>0.05)。结论血清sCD_(44v6)检测在肺癌的辅助诊断、手术疗效和化疗疗效以及预后判断方面具有重要价值。
出处 《肿瘤研究与临床》 CAS 2007年第8期552-553,共2页 Cancer Research and Clinic
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  • 1季峰,郑淑蓓,卢佩琳,崔峻辉,于吉人,厉有名.胃癌患者外周血单个核细胞和肿瘤组织表面分化抗原44变异体6检测的临床意义[J].中华检验医学杂志,2005,28(4):403-405. 被引量:4
  • 2Skelton Tp,J Cell Biol,1998年,140卷,2期,431页
  • 3Guo YJ,Liu G,Wang X,et al.Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer.Cancer Res,1994,54:422-426.
  • 4Yamamichi K,Uehara Y,Kitamura N,et al.Increased expression of CD44v6 mRNA significantly correlates with distant metastasis and poor prognosis in gastric cancer.Int J Cancer,1998,79:256-262.
  • 5Harn HJ,Ho LI,Shyu RY,et al.Soluble CD44 isoforms in serum as potential markers of metastatic gastric carcinoma.Clin Gastroenterol,1996,22:107-110.
  • 6Hong RL,Lee WJ,Shun CT,et al.Expression of CD44 and its clinical implication in diffuse-type intestinal-type gastric adenocarcinomas.Oncology,1995,52:334-339.
  • 7Heider KH,Dammirich J,Petra SA,et al.Differential expression of CD44 splice variants in intestinal and diffuse type human gastric carcinoma and normal gastric mucosa.Cancer Res,1993,53:4197-4203.
  • 8Gastella EM,Ariza A,Pellicer I,et al.Differential expression of CD44v6 in metastases of intestinal and diffuse type of gastric carcinoma.J Clin Pathol,1998,51:134-137.
  • 9Saito H,Tsujitani S,Katano K,et al.Serum cincentration of CD44 variant 6 and its relation to prognosis in patients with gastric carcinoma.Cancer,1998,83:1094-1101.
  • 10Yamaguchi A,Gio T,Yu J,et al.Expression of CD44v6 in advance gastric cancer and its relationship to hematogenous metastasis and long-term prognosis.J Surg Oncology,2002,79:230-235.

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