暴马子皮提取物对四氯化碳所致小鼠急性肝损伤的保护作用

Protective effects of the Syringa reticulata var.mandshurica extract against acute liver injury in mice

[目的]研究暴马子皮提取物对四氯化碳所致小鼠急性肝损伤的影响.[方法]灌胃给予实验动物暴马子皮提取物,用四氯化碳制作小鼠急性肝损伤模型,用比色分析法测定小鼠血清天冬氨酸转氨酶(AST)、丙氨酸氨基转移酶(ALT)、肝组织超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量.[结果]暴马子皮提取物可显著抑制四氯化碳所致小鼠血清AST,ALT浓度的升高,同时可升高肝组织内SOD活性,降低肝组织内MDA含量.[结论]暴马子皮提取物对四氯化碳所致小鼠急性肝损伤具有保护作用.

OBJECTIVE To investigate the protective effects of the Syringa reticulata var. mandshurica aqueous extract against carbon tetrachloride induced acute liver injury in mice. METHODS The Syringa reticulata var. mandshurica aqueous extract was administrated by oral, and the acute hepatic injury models were made by carbon tetrachloride in mice. The activities of ALT and AST in the serum, the concent of MDA and the activity of SOD in liver tissue were investigated by colorimetric method. RESULTS The aqueous extract of Syringa reticulata var. mandshurica significantly decreased the levels of ALT and AST in serum and the content of MDA, but improved the activity of SOD in liver. CONCLUSION The Syringa reticulata var. mandshurica aqueous extract has the protective effects for the acute liver injury induced by CCl4 in mice.