57例运动神经元病临床与肌电图关系的研究

The study of relationship between clinic and electromyogram in 57 cases of motor neuron disease

目的:探讨运动神经元病的临床特点;分析胸段脊旁肌、胸锁乳突肌、肢体肌肌电图及神经电图在运动神经元病中的诊断价值;方法:回顾分析临床确诊为运动神经元病(MND)的57例患者的临床资料,临床初步诊断,统计病程、临床分型不同的病例胸锁乳突肌、胸段脊旁肌及肢体肌肌电图并对其进行分析。结果:57例MND病例均表现广泛神经源性损害。不同临床分型的胸锁乳突肌、胸段脊旁肌肌电图有统计学差异(P<0.05);不同肌群之间的纤颤电位和正锐波程度有统计学差异(P<0.05)。结论:MND病情进展迅速并且预后极差,目前缺乏有效的可逆转性的治疗手段,因此早期正确的诊断对于MND患者至关重要。早期行肌肉电生理检查有助于对MND疾病的早期确诊。常规检测胸锁乳突肌、胸段脊旁肌肌电图有助于MND早期诊断。

Objective： To investigate the clinical characteristics of motor neuron disease （MNS）, to analyze the value of eleetromyogram and electro neurogram of thoracic paraspinal muscle, sternomastoid muscle and appendieular muscles in diagnosis of MNS. Methods： Retrospectively analyzed the 57 patients diag nosed with motor neuron disease and their electromyogram and electro neurogram of thoracic paraspinal muscle, sternomastoid muscle and appendicuiar muscles. Results： Extensive neurogenie damage was found in the 57 cases of MND. There were significant differences between the course of disease and the degree of fibrillation potential and positive sharp wave （P 〈0.05）. Among which, there were 2 cases of motor conduction velocity stepping down and only 1 patient with diabetic peripheral angiopathy showed sensory nerves conduction velocity stepping down. Conclusions： Early muscle electrophysiology examination may be helpful for MND diagnosis in early stage. Muscle electromyogram examination for sternomastoid muscle and thoracic paraspinal muscle should be taken as routhte examination for early diagnosis for MND.