低强度氦氖激光血管内照射对家兔血栓素、前列环素及脂质过氧化物的影响

The effect of ILLLI on the TxB_2,6-keto-PGF_(1α) in cholesterol fed rabbits

通过观察低强度氦氖激光血管内照射（ILLLI）对饲脂家兔血浆中血栓素B2（TxB2）、6-酮-前列腺素F1α（6－keto－PGF1α）、脂质过氧化物（LPO）、TxB2／6-keto－PGF1α及主动脉和冠状动脉病理学改变，探讨ILLLI预防动脉粥样硬化（AS）的机制。结果表明：ILLLI可显著降低TxB2、LPO及TxB2／6－keto－PGF1α（P＜0.01），而对6-keto-PGF1α无升高作用（P＞0．05）。主动脉粥样斑块面积百分比与TxB2、LPO呈显著正相关（r=0．8641，P＜0．01），与6-keto－PGF1α是显著负相关（r=-0.7432，P＜.05）。光镜观察，ILLLI治疗后主动脉及冠状动脉粥样斑块病变程度明显减轻。提示：ILLLI具有预防AS的作用。

The purpose of this study was to elucidate the mechanism and evaluate the efficacy of intravascular low-lever laser irradiation therapy on blood (ILLLI) of cholesterol fed rabbits in prevention atherosclerosis (AS) by measuring thromboxane B2 (TxB2 ), 6-keto-PGF1α,lipid peroxide (LPO) and histomorphometry of aorta and coronary arteries. The result indicated that ILLLI could significantly decrease TxB2, LPO and TxB2/6-keto-PGF1α (P <0. 01 ), but 6-keto-PGF1α was no statistical difference (P >0.05). Meantime a positive and a negative correlation existed between atbermatous lesion percent of the intimal surface of aorta and TxB2,LPO and 6-keto-PGF1α respectively. Thus ILLLI might have good effect in prevention of AS.