丙型肝炎患者血清sTNFR水平及其临床意义的探讨

Levels of serum STNFR in patients with hepatitis C and its clinical significance

目的探讨丙型肝炎患者血清中sTNFR水平及其临床意义。方法用ELISA双抗体夹心法,检测68例丙型肝炎患者血清可溶性肿瘤坏死因子受体(sTNFR)。结果重型肝炎及慢性活动性肝炎与健康对照组有显著差异(P<0.01),sTNFR水平升高程度与病情呈正相关。结论测定丙型肝炎患者血清sTNFR水平,对判断病情及预测转归有一定参考价值。

Objective： To detect the levels of serum STNFR in patients with hepatitis C and explore its clinical significance. Methods： Levels of serum STNFR were detected by enzyme linked immunosorbent assay （ELISA） in 68 cases infected with hepatitis C virus. Results： The levels of serum STNFR in patients with severe hepatitis and in patients with chronic active hepatitis were higher than those in normal controls, and the difference between them had statistical significance （ P 〈 0. 001 ）. There was positive correlation between serum levels of STNFR and the disease. Conclusion ： The levels of serum STNFR in patients with hepatitis C have certain value in deciding state of hepatitis C and predicting prognosis of hepatitis C.