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北京地区乳腺癌危险因素分析 被引量:13

Analysis of the risk factors of breast cancer in Beijing areas
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摘要 目的探讨北京地区女性乳腺癌发生的危险因素,为乳腺癌的预防提供客观依据。方法以人群为基础进行病例对照研究,2006年11月-2007年4月按照地区代表性分层随机抽样方法,抽取东城区(城区)、海淀区(近郊区)、通州区(远郊区)的住院乳腺癌术后随访患者共858例作为乳腺癌组,门诊健康体检者781例作为对照组。研究对象均为35~60岁女性,北京市户口,且在当地居住5年以上,对其进行相关问卷调查,内容包括:社会经济及人口学特征,生理、生育情况,遗传、生物学情况,心理精神状况,日常生活与工作情况等。结果绝经年龄超过55岁、负性情绪、不良生活事件、亲属有乳腺癌家族史、体重指数(BMI)≥25、受教育程度低、性格内向、5年内每天静坐时间超过3h等都是北京地区女性患乳腺癌的危险因素,而母乳喂养、妊娠次数>3次则能降低乳腺癌发生的危险。结论北京地区女性发生乳腺癌不但与生理、遗传因素有关,而且与精神、心理因素有密切联系。加强预防乳腺癌的健康教育,提高妇女知识水平,倡导健康的生活方式,可以减少乳腺癌的发生。 ObJective To analyze the risk factors of breast cancer (BC) in Beijing areas, in order to provide scientific basis for pre vention of breast cancer. Methods The stratified random sampling was performed from Nov. 2006 to Apr. 2007 on district basis. Eight hundred and fifty-eight hospitalized patients with breast cancer, who were followed up after operation, from Dongcheng District (downtown area), Haidian D. (suburb) and Tongzhou D. (exurbun) were selected as BC group, and other 781 women receiving medical examination were enrolled as control group. All the investigated subjects were Beijing residents, age from 35--60 years, and had lived in Beijing for longer than 5 years. The items in questionnaire included societal and economic status, and physiological conditions, fertility, heredity, biological and psychological status, daily life and work condition, and so on. Results The risk factors for breast cancer in Beijing areas included the menopause age after 55 years, negative emotion, negative life events, family history of breast cancer, BMI over 25, low education, introverted character, and sedentary over 3 hours each day for 5 years. However, breast feeding and number of pregnancies over three may decrease the risk of breast cancer. Conclusions The risk factors for breast cancer in Beijing areas are not only related to physiological and genetic conditions, but also to mental and psychological status. The incidence of breast cancer may be lowered by enhancing the knowledge of prevention of breast cancer and initiating a healthy life style.
出处 《解放军医学杂志》 CAS CSCD 北大核心 2009年第5期605-607,共3页 Medical Journal of Chinese People's Liberation Army
基金 乳腺癌危险度评价及健康教育项目
关键词 乳腺肿瘤 危险因素 病例对照研究 breast neoplasms risk factors case-control studies
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