摘要
上世纪70年代,美国哥伦比亚大学Bassett率先将脉冲电磁场用于骨折治疗,证实了脉冲电磁场可以促进骨折愈合。经过30多年的发展,脉冲电磁场已作为一种非侵入的疗法成功运用于临床,并取得了非常好的效果。通过细胞实验研究、动物实验研究、临床应用研究、作用机理4方面综述了脉冲电磁场促进骨折愈合的研究进展,分析了影响脉冲电磁场作用效果的各种因素,并在此基础上介绍了此方面研究中还需进一步探讨的问题,以及脉冲电磁场用于治疗骨折的广阔应用前景。
Fracture is a kind of common disease in clinical field, but there are many difficult and complicated cases such as bone nonunion. The traditional treatment relies on bones transferring or internal fixation, which leads to a high ratio of risk to cure, and brings extreme pains to patients. In 1970s, Mr. Bassett from Colombia University took the lead in using pulsed electromagnetic fields (PEMFs) for fracture therapy, and confirmed PEMFs could help to heal fractures. PEMFs presents many perfect performances in fracture treatments such as that it causes no other injury, is easy to be operated, has wide application, and has no complications, etc. PEMFs' positive performances are free from time of fractures, injury of skin or nerve, age and gender of patients, and times of failure in operation, etc. , especially :for local infection. During last 30 years, as the non-invasive therapeutics, PEMFs has been applied to clinical medicine successfully with perfect results. However, it's functioning mechanism is still unclear, mainly includes piezoelectriceffect theory, calcium ion deposition theory and secondary messengers theory. It's therapeutic efficacy is also affected by PEMFs' parameters, such as frequency, intensity and wave form. This paper presents the development of PEMFs' positive performance in fractures treatments through following four aspects: cell experiment study, animal experiment study, clinical application study, and functioning mechanism, analyses all factors that affect PEMFs' performance, and then expands several issues needing further study and future development of PEMFs application in fracture therapy.
出处
《高电压技术》
EI
CAS
CSCD
北大核心
2009年第5期1111-1117,共7页
High Voltage Engineering
基金
国家自然科学基金重点项目(50637020)~~
关键词
脉冲电磁场
骨折愈合
医学研究
作用机理
脉冲参数
生物效应
pulsed electromagnetic fields(PEMFs)
fracture healing
medical study
functioning mechanism
pulse parameter
bioeffect