肾病综合征患者血小板参数测定及临床意义观察

Platelet Parameter Determination in Nephrotic Syndrome Patients and Clinical Observation

目的：研究肾病综合征患者血小板参数的变化。方法：采用SYSMEX XE-2100血细胞分析仪对57例肾病综合征（NS）患者抗凝治疗前后及50名健康体检者的PLT、MPV、PDW进行对照研究。结果：NS组治疗前与治疗后PLT（P〈0.05）有显著差异,MPV和PDW（P〈0.01）有非常显著差异;NS组治疗前与对照组PLT（P〉0.05）无显著差异,MPV和PDW（P〈0.01）有非常显著差异;NS组治疗后与对照组PLT、MPV和PDW（P〉0.05）均无显著差异。说明肾病综合征患者的血液高凝状态与血小板功能增强关系密切。结论：MPV和PDW的检测可作为肾病综合征患者病情变化和适时掌握血小板抗凝治疗的一项参考指标。

Objective： To study the change of platelet parameter in nephrotic syndrome patients. Method： PLT, MPV and PDW were detected with SYSMEX XE--2100 hematology analyzer in 57 nephrotic syndrome （NS） patients before and after anticoagulant therapy and compared with that in 50 healthy cases. Result： PLT in NS group had remarkable difference before and after treatment （P〈0.05）, MPV and PDW had very remarkable difference （P〈0.01） ; PLT in NS group before treatment had remarkable difference with that in control group （p〉0.05）, MPV and PDW had very remarkable difference （P〈0.01） ; there had no obvious difference in PLT, MPV and PDW in NS group after treatment and control group. It shows that NS patients＇ high blood coagulation state is closely rdated to the strengthening of platelet function. Conclusion： The determination of MPV and PDW can be regarded as a reference index for disease changing and timely mastering of anticoagulant therapy in NS patients.