摘要
目的本研究旨在通过观察高血压病患者组织纤维化血清学指标的变化,以探讨其作为心肌肥厚指标的临床价值。方法测定高血压伴左室肥厚36例,高血压不伴左室肥厚31例及正常对照30例血清中Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)、透明质酸(HA)的含量。并将左室心肌重量指数(LVMI)与上述各参数作相关分析。结果高血压伴左室肥厚组较高血压不伴左室肥厚组及正常对照组的血清PCⅢ、LN、HA含量显著增高(P<0.01);血清PCⅢ、LN、HA均与LVMI呈显著正相关。结论血清PCⅢ、LN、HA均可作为高血压左室肥厚患者组织纤维化的血清学指标,为临床诊断高血压心肌肥厚提供间接的依据。
Objective To investigate the changes of serum fibrotic indices in essential hypertensive patients.Methods Serum procollagen type Ⅲ (PCⅢ), laminin (LN) and hyaluronic acid (HA) were measured by radioimmunoassay in 36 essential hypertensive patients with left ventricular hypertrophy (LVH), 31 essential hypertensive patients without LVH and 30 healthy subjects. The correlations between left ventricular mass index (LVMI) and the parameters above mentioned were analyzed.Result Serum PCⅢ, LN and HA were significantly increased ( P <0.01) in hypertensive patients with LVH as compared with those without LVH and healthy subjects. Serum PCⅢ, LN and HA positively correlated with LVMI in the group of hypertensive patients. Conclusion These findings suggest that measurements of PCIII, LN and HA may provide indirect diagnostic information on myocardial fibrosis associated with arterial hypertension.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第3期209-211,共3页
Chinese Journal of Cardiology
关键词
高血压
左室肥大
心肌纤维化
hypertension hypertrophy, left ventricular myocardial fibrosis