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PTEN在乳腺癌中的表达及其与转移的关系 被引量:7

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摘要 目的通过检测PTEN基因在乳腺癌组织中的表达探讨其临床病理意义。方法采用逆转录聚合酶链反应(RT-PCR)检测PTEN在40例乳腺癌中的表达。结果乳腺癌组织与正常乳腺组织和癌旁组织PTEN的表达有显著差异(P<0.01,P<0.05)。PTEN在早期浸润性癌和晚期浸润性癌阳性表达率差异显著(P<0.05);在淋巴结转移组与无淋巴结转移组检出阳性率差异显著(P<0.01)。结论PTEN表达与乳腺癌临床病理特征和生物学行为存在密切关系;PTEN基因是乳腺癌细胞增生活跃的重要影响因素。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第11期1390-1392,共3页 Chinese Journal of Gerontology
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同被引文献65

  • 1李锦毅,郑华川,杨琳,徐蕾,杨雪飞,高红,张荫昌,辛彦.胃癌中PTEN异常表达与围基因微卫星的杂合性缺失[J].中华肿瘤杂志,2004,26(7):389-392. 被引量:32
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