星状神经节阻滞治疗围绝经期综合征患者的激素水平变化及疗效分析

Effect of stellate ganglion block in the treatment of perimenopausal syndrome.

目的观察星状神经节阻滞（SGB）治疗妇女围绝经期综合征的临床疗效。方法选择我院2007年2月至2008年12月经妇科门诊确诊为围绝经期患者30例，均进行阴道细胞学检查，并检查血雌二醇（E2），促卵泡生成素（FSH），黄体生成素（LH），符合围绝经期综合征而无其他慢性疾病，且近3个月均未服用过激素类药物。采用前入路SGB，每日1次，左右交替进行，每10次为1疗程，均治疗2个疗程。记录患者治疗前后血FSH、LH、E2的变化。结果血中E2由治疗前的（31．29±19．36）pmol／L升高至（159．47±88．21）pmol／L（t=-24．976，P〈0．01），FSH由治疗前的（54．67±19．24）U／L下降至（38．15±13．50）U／L（t=13．872，P〈0．01），LH由治疗前的（36．1±15．6）U／L下降至（26．7±8．7）U／L（t=9．188，P〈0．01）。围绝经期综合征的主要症状潮热出汗、失眠、心悸、关节痛、肌痛、阴道干涩的改善总有效率为91％、92％、85％、87％、88％。结论SGB可调整围绝经期自主神经平衡失调，使已紊乱的自主神经和内分泌功能达到新平衡，是消除围绝经期综合征的有效治疗方法。

Objective To observe the effect of stellate ganglion block （SGB） in the treatment of peri-menopause syndrome of clinical efficacy. Methods 30 patients diagnosed as perimenopausal syndorme by the gynecology clinic in our hospital from February 2007 to December 2008 were selected. All patients experienced vaginal cytology and examination of blood estradiol （ E2 ）, follicle-stimulating generation Su （FSH） , luteinizing hormone （ LH）, in line with perimenopausal syndrome and no other chronic diseases, and in the last 3 months the patients had not taken hormone treatment drugs. Anterior SGB once a day, around the turn was adopted, taking 10 times as a course of treatment. All patients were treated for two courses. The blood FSH, LH, E2 changes were recorded. Results Blood E2 increased from （31.29 ± 19.36） pmol/L to （ 159.47 ± 88.21 ） pmol/L （ t = - 24. 976, P 〈 0.01 ）. FSH decreased from （54.67±19.24）U/L to （38.15 ±13.50） U/L （t=13.872,P〈0.01）,and LH dropped from （36.1 ± 15.6） U/L to （26.7 ± 8.7 ） U/L （ t = 9. 188, P 〈 0.01 ）. Conclusion SGB has the disorder and autonomic Endocrine function to achieve a new balance because it can adjust perimenopausal autonomic nervous imbalance, so it is the effective treatment for elimination of peri-menopause syndrome.