窄带噪声暴露后豚鼠血SOD、MDA和GSH的变化

Changes of T-SOD Activity and MDA、GSH Contents in Blood of Guinea Pigs after Exposure to Narrow-Band Noise.

为评价强噪声暴露后体内自由基引起的脂质过氧化反应的变化，将豚鼠６０只随机分为５组，２组正常对照，３组暴露噪声（１２６ｄＢＳＰＬ，３ｈ／ｄ，连续５ｄ或１０ｄ）。豚鼠血清超氧化物歧化酶（ＳＯＤ）的活力、血清丙二醛（ＭＤＡ）和全血谷胱甘肽（ＧＳＨ）的含量。结果发现，噪声暴露５ｄ，血清ＳＯＤ增加；暴露１０ｄ，ＳＯＤ降低（Ｐ都大于０．０５）。ＭＤＡ的含量随暴露时间延长增加（Ｐ＜０．０５）；ＧＳＨ的含量随暴露时间的延长降低（Ｐ＜０．０１）。表明，强噪声暴露后自由基引起的脂质过氧化反应增强。提示。

In order to evaluate the changes of lipid peroxide response induced by free radical after intense noise exposure,levels of T-SOD and MDA in serum and GSH in blood of guinea pigs were determined.Sixty male adult guinea pigs were used.The narrow band noise was centered at 1000Hz with 100Hz band width 126 dB SPL.It was found:1) SOD activity in serum increased after 5d exposure (P>0.05),but decreased after 10d exposure (P>0.05);2)contents of MDA in serum increased (P<0.05) and contents of GSH in blood decreased with increase of exposure time (P<0.01).It shows that the lipid peroxide response induced by free radicals increased after intense noise exposure and it is possible to use free radical scavengers and/or antioxidant in prevention and treatment of noise induced damage.