低剂量γ射线对小鼠血清特异性溶血素产生的刺激作用

HORMESIS OF SPECIFIC HEMOLYSIN PRODUCTION IN MICESERA BY LOW DOSE γ-RAYS

选择昆明种雄性小白鼠以^(60)Coγ射线单次整体照射2．5～10cGy后9h，用绵羊红细胞（SRBC）免疫，免疫后4d小鼠血清特异性溶血素水平显著高于对照（p＜0．05或p＜0．01），其中10cGy为最适宜刺激剂量。小鼠照射10cGy后9h免疫，在免疫后不同时间测定血清特异性溶血素水平，其结果表明照射组溶血素水平峰值显著高于对照组峰值（p＜0．05），而且峰值出现的时间提前。小鼠照射10cGy后不同时间用SRBC免疫，结果受照射后1d、3d、7d免疫组小鼠血清特异性溶血素水平显著高于对照（p＜0．05），而14d和21d组与对照组无显著性差异，说明低剂量γ射线诱导的特异性体液免疫刺激作用可持续1～2周。

The effects of low dose single whole-body irradiation on the specific hemolysin level in mice sera were studied in male Kunming strain mice, 18-22g, aged 6-8 weeks. The mice were immunized intraperitoneally with sheep red blood cells (SRBC) after exposure to low dose Cobalt-60 γ-rays. The results showed that: (1) the levels of hemolysin in mice exposed to 2.5~10 cGy were significantly higher than those of control (p<0.05 or p<0.01), and the maximum response occurred at 10cGy, so the optimum stimulating dose is 10cGy; (2) irradiation of 10cGy caused that the peak level of specific hemolysin in sera appeared earlier and significantly higher than that of control; (3)the hormesis of specific hemolysin induced by 10cGy γ-rays could last 1 to 2 weeks.