摘要
电穿孔基因作为非病毒递送手段之一,可安全、有效地将外源核酸导入靶组织或器官。近年来用电穿孔法进行基因治疗的报道不断增多,优势日趋显著。本文重点阐述了电穿孔在基因治疗中的优势、影响因素及在临床前和临床试验中应用。
Abstract: The electroporation can delivery the exogenous nucleic acid into the target tissue or the organ effectively and safely as one of the non-virus delivery methods. In recent years, electroporation has been adopted in the gene therapy studies with significant increasingly advantages. This article mainly elaborated the superiority of electroporation in gene therapy and the influencing factors, as well as the applications in the preclinical and clinical trial.
出处
《生命科学》
CSCD
北大核心
2009年第3期467-471,共5页
Chinese Bulletin of Life Sciences
关键词
电穿孔
基因治疗
临床前研究
临床试验
electroporation
gene therapy
preclinical trial
clinical trial