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血管内皮生长因子C在宫颈癌组织表达及其意义 被引量:5

EXPRESSION AND CLINICAL SIGNIFICANCE OF VEGF-C IN CERVICAL CANCER
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摘要 目的探讨血管内皮生长因子C(VEGF-C)在宫颈癌发生发展中的作用。方法选取宫颈鳞癌组织68例、宫颈上皮内瘤样变及原位癌(CIN)组织25例、正常宫颈组织12例,采用SP免疫组化染色方法检测VEGF-C的表达。结果宫颈癌组织VEGF-C表达阳性率明显高于正常宫颈组织及CIN组织,差异有显著性(χ2=4.10、4.53,P<0.05)。有淋巴结转移宫颈癌组织的VEGF-C表达阳性率明显高于无淋巴结转移组织(χ2=6.11,P<0.05)。VEGF-C表达与宫颈癌的病理分级有关,低分化宫颈癌组织中VEGF-C表达阳性率高于中高分化癌组织,差异有显著性(χ2=6.01,P<0.05)。结论VEGF-C表达与宫颈癌的发生发展相关,对宫颈癌的分化及淋巴结转移可能起促进作用。 Objective To study the effect of vascular endothelial growth factor-C (VEGF-C) on the occurrence and development of cancer of the cervix. Methods Immunohistochemical method was used to detect the expressions of VEGF-C in 68 squamous-cell-cancer (SCC) samples, 25 cervical-intraepithelial-neoplasia (CIN) samples and 12 normal-cervical-tissue (NCT) samples. Results The expression rate of VEGF-C in SCC was manifestly higher than that in the NCT and CIN, the differences were significant (x^2=4.10, 4. 53 ; P〈0.05). The higher expression of VEGF-C was seen in SCC with lymph-node metastasis than that without metastasis (X^2 = 6.11 ,P〈0.05), its expression was associated with the pathological grading of cervical cancer, which was higher in the poorly differentiated than that in the moderately and well differentiated, the differences were significant (X^2 = 6.01,P〈0.05). Conclusion The expression of VEGF-C is involved in oncogenesis and development of cervical cancer, which may promote the differentiation and lymph node metastasis of this malignancy.
作者 张红 王言奎
出处 《齐鲁医学杂志》 2009年第4期304-305,308,共3页 Medical Journal of Qilu
关键词 子宫颈肿瘤 血管内皮生长因子C 淋巴转移 Cervix neoplasms Vascular endotheiial growth factor C Lymphatic metastasis
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