水通道蛋白1在宫颈病变中的表达及意义

Expression and significance of AQP1 in different stages of human cervical lesions

目的:检测宫颈病变组织中水通道蛋白1的表达,探讨该蛋白在宫颈癌形成和演进进程中的意义。方法:用免疫组织化学SP法检测83例石蜡包埋宫颈组织中水通道蛋白1的表达,结合临床病理分型分析其表达的意义。结果:水通道蛋白1在慢性宫颈炎、宫颈上皮内瘤样病变(CIN)和宫颈癌组织中的阳性率分别为4.0%,33.3%和74.2%,3组样本中水通道蛋白1阳性率的差异有统计学意义(P<0.05),宫颈癌病理学分级1+2级和3级相比,差异有统计学意义(P<0.01)。水通道蛋白1表达阳性率与CIN的分级,与宫颈癌临床分期、组织学分型和淋巴结转移无关(P>0.05)。结论:水通道蛋白1在宫颈癌前病变和宫颈癌组织中表达升高,可能在宫颈癌的发生发展过程中起重要作用。

Objective：To detect the expression of aquaporin-1 （AQP1） protein in different stages of human cervical lesions and further to explore its possible role in tumor formation and progression. Method：Eighty three paraffin embedded specimens of the cervical lesions with different stages were examined with SP immunohistochemical methods, against AQP1. Results： The positive rates of AQP1 expression in cervicitis,cervical intraepithelial neoplasia（CIN） and cervical cancer were 4.0% , 33.3% and 74.2% respectively, which had significant difference （ P 〈 0.05 ）. The expression of AQP1 in cervical cancer had no association with FIGO stage, histological grade and lymph node metastasis （ P 〉 0.05 ）, but had significant association to the pathologic grade （ G1 ＋ G2 compared with G3 ） （ P 〈 0.05 ）. Conclusion ： Overexpression of AQP1 may be involved in the formation of cervical cancer.