膀胱肿瘤尿中纤溶分子标志物D-二聚体测定的意义

The significance of D-Dimer in urine in patients with bladder cancer

目的：测定膀胱肿瘤患者尿中D－二聚体含量，探讨D－二聚体与膀胱肿瘤的关系及其应用价值。材料与方法：定量酶联免疫吸附试验测定43例患者。结果：肿瘤患者尿中D－二聚体平均含量高于非肿瘤患者和正常对照（P＜0.05）。非肿瘤患者与正常对照之间无显著性差异（P＞0．05）。术后肿瘤患者及非肿瘤患者尿中D－二聚体合量较术前增高（P＜0．05），肿瘤患者高于非肿瘤患者（P＜0．05）结论：膀胱肿瘤患者尿中D－二聚体含量发生改变，尿中D－二聚体可作为监测肿瘤患者的指标之一。手术创伤可导致尿中D－二聚体含量增加。

Objective: The D -dimer in urine were measured in bladder cancer patients to evaluate its application value in monitoring bladder tumors. Methods: Enzyme linked immunospecific assay. Results: The urine content of D -Dimer in patients with b^r cancer are significanily increased when compared to non -tumor patients and normal group (P < 0. 05 ) . There are no differences between non -tumor patients and normal group. The urine content of D -Dimer in post-operative patients were higher than pre -operative hath in tumor and non -tumor patients, but the urine content of D -Dimer in post - operative patients with bladder cancer were higher than non -tumor patients. Conclusion: The patients with bladder cancer are in a state of secondary fibrinolysis, D -Dimer can be usal as a marker of monitoring bladder cancer. Operative trauma can enhanCe the state of fibrinolysis in patients with bladder cancer.