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肝门阻断对肠道影响的实验研究 被引量:5

Influence of portal triad clamping on the intestine in pigs
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摘要 为了解肝手术后肝昏迷等并发症的发生机制,阻断猪肝门45min后松钳60min,造成肠瘀血动物模型;观察小肠粘膜的变化,并检测血中肠源性毒物。结果发现:肝门阻断后血中组织蛋白酶D,内毒素及乳酸明显增高,且肠粘膜出现明显损伤。提示肝手术后并发症的发生与上述结果有关。 A pig model of liver ischemia and intestinal congestion was made by portal triad clamping(PTC) for 45 minutes to investigate the influence of PTC on intestine. The results were as follows: ① The level of cathepsin D was increased significantly after PTC as compared with the value before clamping (P<0.05); ② The endotoxin and lactic acid were significantly increased after PTC comparing with those of preclamping (P<0.05,P<0.01) and the control group (P<0.05,P<0.01); ③ The intestinal mucosa had a significant damage (P<0.05) after PTC. The results indicate that PTC can result in intestinal mucosal lesion and enterotoxin absorption. Therefore, the protection of intestinal functions is important in hepatic surgery and preoperative bowel preparation should be done.
出处 《湖南医科大学学报》 CSCD 1998年第3期246-248,共3页 Bulletin of Hunan Medical University
基金 湖南省计委科技攻关资助
关键词 肝疾病 外科手术 肝门阻断 肠粘膜 liver diseases surgery portal triad clamping intestinal mucosa enterotoxin cathepsin D swine
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  • 1刘鹏熙,中华消化杂志,1991年,11卷,26页

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