摘要
为了解肝手术后肝昏迷等并发症的发生机制,阻断猪肝门45min后松钳60min,造成肠瘀血动物模型;观察小肠粘膜的变化,并检测血中肠源性毒物。结果发现:肝门阻断后血中组织蛋白酶D,内毒素及乳酸明显增高,且肠粘膜出现明显损伤。提示肝手术后并发症的发生与上述结果有关。
A pig model of liver ischemia and intestinal congestion was made by portal triad clamping(PTC) for 45 minutes to investigate the influence of PTC on intestine. The results were as follows: ① The level of cathepsin D was increased significantly after PTC as compared with the value before clamping (P<0.05); ② The endotoxin and lactic acid were significantly increased after PTC comparing with those of preclamping (P<0.05,P<0.01) and the control group (P<0.05,P<0.01); ③ The intestinal mucosa had a significant damage (P<0.05) after PTC. The results indicate that PTC can result in intestinal mucosal lesion and enterotoxin absorption. Therefore, the protection of intestinal functions is important in hepatic surgery and preoperative bowel preparation should be done.
出处
《湖南医科大学学报》
CSCD
1998年第3期246-248,共3页
Bulletin of Hunan Medical University
基金
湖南省计委科技攻关资助
关键词
肝疾病
外科手术
肝门阻断
肠粘膜
liver diseases
surgery
portal triad clamping
intestinal mucosa
enterotoxin
cathepsin D
swine