人体常温下阻断和恢复入肝血流后肝组织病理与超微结构的临床研究

THE CLINICAL STUDIES OF PATHOLOGIC AND ULTRASTRUCTURAL ALTERATIONS OF LIVER AFTER HEPATIC VASCULAR OCCLUSION UNDER NORMOTHERMIA IN HUMAN

采用常温下阻断入肝血流后行肝切除手术２０例，并同时于不同时间及恢复血流后切取肝脏微型标本行光镜及电镜检查。结果显示：一次性阻断肝门３０分钟以内者，其肝脏病理及超微结构的损伤性变化是可复性的。

To evaluate the biological tolerance of the human liver to prolonged warm ischemia, 20 patients who underwent liver resections with hepatic inflow occlusion are reported. Biopsy of liver were performed during and after consecutive periods of hepatic ischemia, and speciments were observed under light and electron microscope. The results showed that hepatic vascular occlusion for <30 min, resulted in atotissular temporary but reversible pathologic and ultrastructural changes in liver, even patients with liver cirrhosis had better recovery from the operation when the hepatic ischemia was lengthen up to 40 min.