高同型半胱氨酸血症与冠状动脉粥样硬化性心脏病关系的研究进展

Advances in Research in Relationship Between Hyperhomocysteinemia and Coronary Heart Disease

高同型半胱氨酸血症作为冠心病的独立危险因素已受到重视。其通过导致血管内皮损伤、促进炎性因子的释放、刺激血管平滑肌细胞增生及钙化、影响脂质代谢、促进动脉血栓形成等途径引起动脉粥样硬化。大量的研究还证实高同型半胱氨酸血症是冠心病的独立预测因子,不仅可用于判断冠心病及其严重程度,还可用于判断急性冠脉综合征和介入治疗的预后。

Hyperhomoeysteinemia should be given attention as an independent risk factor of coronary heart disease （ CHD ）. It induces atherosclerosis by causing vascular endothelial dysfunction, promoting the release of inflammation factors, stimulating vascular smooth muscle cells to hyperplasia and calcification, influencing the metabolism of lipids, and advancing arterial thrombosis. A growing body of research has confirmed that not only is hyperhomocysteinemia an independent predictor of coronary heart disease, but it can indicate the degree of CHD in a patient, and serve to predict the outcome of interventional therapy.