应用Tei指数评价妊娠期糖尿病胎儿心功能的研究

Investigation on cardiac function of gestational diabetes fetuses evaluated by Tei index

目的:应用超声心动图Tei指数测定妊娠期糖尿病胎儿心室的功能,探讨Tei指数评价妊娠期糖尿病胎儿心室功能的价值。方法:选择正常妊娠孕妇260例及妊娠期糖尿病孕妇136例作为研究对象,其中妊娠期糖尿病组根据血糖控制情况分为3组,血糖控制良好组69例,血糖控制不良组42例,血糖未控制组25例。应用多普勒超声心动图测定各组胎儿左、右心室的Tei指数。结果:正常妊娠组胎儿左、右心室Tei指数与孕周呈负相关,与胎心率无相关性;妊娠期糖尿病各组胎儿的左、右心室平均Tei指数均高于正常妊娠组,以血糖控制不良组及血糖未控制组明显,差异具有统计学意义(P<0.05)。在妊娠期糖尿病各组中,血糖控制不良组及血糖未控制组胎儿的左、右心室平均Tei指数均显著高于血糖控制良好组,差异具有统计学意义(P<0.05)。结论:Tei指数可作为临床综合评估妊娠期糖尿病胎儿心肌受累的一项简单可靠指标。

Objective： To evaluate the myocardial systolic and diastolic function of fetal heart of gestational diabetes mellitus （ GDM ） by Tel index, explore the value of Tel index in fetuses with GDM. Methods： 260 healthy pregnant women and 136 pregnant women with GDM were selected, then the 136 GDM cases were divided into well - controlled blood glucose group （69 cases ） , bad - controlled blood glucose group （42 cases ） and non - treatment group （ 25 cases） . The Tel indexes of left ventrieular （ LV ） and fight ventrieular （RV） were detected by echocardiography. Results： There was negative correlation between Tel indexes of LV, RV and gestational weeks, and independent of heart rate. The Tel indexes of LV and RV in GDM group were significantly higher than those in normal group, especially bad - controlled blood glucose group and non - treatment group （ P 〈 0. 05 ） . The Tel indexes of LV and RV in bad - controlled blood glucose group and non - treatment group were higher than those in well - controlled blood glucose group （ P 〈 0. 05 ） . Conclusion： Tel index is a simple and reliable index of quantitative assessment of ventricular function in fetuses with GDM.