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醒酒保肝胶囊对酒精性肝损伤保护作用的实验研究 被引量:2

Study on protective effects of Xingjiubaogan capsule on alcohol liver injury in rats
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摘要 目的:探讨醒酒保肝胶囊对大鼠酒精性肝损伤的保护作用。方法:60只健康雄性Wistar大白鼠随机分为对照组、造模组、醒酒保肝胶囊低(200 mg/kg)、中(400 mg/kg)、高剂量(1 200 mg/kg)组,实验周期2个月,测定并比较各组实验动物体重增长情况,血清总蛋白(TP)、白蛋白(Alb),谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清中甘油三酯(TG)、超氧化物歧化酶(SOD)的水平;肝组织匀浆中丙二醛(MDA)、还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)的含量和活性。结果:(1)醒酒保肝胶囊各剂量组动物与造模组动物比较体重增长无统计学意义。(2)醒酒保肝胶囊各剂量与造模组比较血清TP、Alb含量升高,ALT、AST、TG含量下降,差异均有统计学意义(P<0.05~0.01)。(3)醒酒保肝胶囊中、高剂量组与造模组动物比较,肝组织匀浆中MDA含量明显下降(P<0.05~0.01),醒酒保肝胶囊高剂量组肝组织匀浆中GSH、GSH-Px活性和血清SOD的含量明显上升(P<0.01)。结论:醒酒保肝胶囊对大鼠酒精性的肝损伤有一定保护作用。 Objectives: To study the protective effects of Xingjiubaogan capsule against the alcohol liver injury in rats. Methods: Randomly distribute 60 male Wistar rats to control group, model group, and low-, middle-, high-dose groups of Xingjiubaogan capsule (200, 400,1 200 mg/kg). Two months later, the body weight, serum total protein (TP), albumin (Alb), alanine transaminase (ALT), aspartate transaminase (AST), triglyceride (TG), superoxide dismutase (SOD) contents, liver glutathione (GSH), glutathione perioxidase (GSH-Px) activities, malondialdehyde (MDA) content were determined and compared between groups. Results: Treatment with different doses of Xingjiuhaogan capsule could significantly increase serum TP, Alb, SOD levels and (P 〈0.05-0.01), and GSH, GSH-Px activities in liver tissue (P 〈0.01), decrease serum ALT, AST, TG levels (P 〈0.05-0.01) and MDA content in liver tissue (P 〈0.05- 0.01). Conclusions: The Xingjiubaogan capsule could ameliorate alcohol liver injury to different degrees in rats.
出处 《新疆医科大学学报》 CAS 2009年第7期858-860,共3页 Journal of Xinjiang Medical University
关键词 醒酒保肝胶囊 酒精性肝损伤 抗氧化 Xingjiubaogan capsule alcoholic liver injury antioxidation
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