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熊去氧胆酸治疗妊娠期肝内胆汁淤积症 被引量:14

Treatment of intrahepatic cholestasis during pregnancy with ursodesoxycholic acid.
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摘要 目的:评估熊去氧胆酸(UDCA)治疗妊娠期肝内胆汁淤积症(ICP)的效果。方法:选择60例ICP病人,分成两组,观察组(n=30)采用UDCA100mg每日3次,对照组(n=30)采用黄疸茵陈冲剂20g每日3次,观察治疗效果。结果:观察组瘙痒评分治疗1周后明显下降,血ALT、TBA、CHO、TG也明显下降(P<005),而对照组下降缓慢,同时还发现观察组产时缺氧发生率低,孕周较长,新生儿体重较重,剖宫产率较低,P<005。结论:UDCA是治疗ICP安全有效的药物。 Objective:To observe the effect of ursodesoxycholic acid(UDCA)on the patients of intrahepatic cholestasis of pregnancy(ICP).Methods:Sixty cases with ICP were divided into study group and control group at random.The patients of study group(n=30)were administrated with UDCA 100mg tid and the patients of control group(n=30)received Yin-Cheng-Chong-Ji 20g tid.Results:No adverse reaction were detected in all patients.During UDCA therapy a statistically significant improvement on pruritus,serum total bile acid levels,serum glulamic pyruvic transaminase,triglycerides and cholesterol were found Only 4 cases of the patients had fetal distress during intrapartum,2 cases of newborn had and Apgar<8 and the mean birth weight were(3204.5±150.4)g.Conclusion:UDCA was a safe and effective drug in the treatment of ICP.
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 1998年第4期215-217,共3页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 熊去氧胆酸 肝内 胆汁淤积 妊娠合并症 Ursodesoxycholic acid\ Intrahepatic cholestasis of pregnancy\ Pregnancy
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