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羧甲基壳聚糖银对实验性大鼠牙周炎的治疗作用 被引量:10

Therapeutic effect of silver carboxymethyl chitosan on experimental periodontitis in rats
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摘要 目的:研究羧甲基壳聚糖银(CMCT-Ag+)对实验性大鼠牙周炎的治疗作用及机制,为研制具有高效杀菌作用的治疗牙周炎药物提供依据。方法:以钢丝结扎大鼠上颌右侧第一磨牙、涂牙龈卟啉菌和饲喂高糖软饲料方法建立实验性大鼠牙周炎模型。实验分正常组、模型组、替硝唑组和12.5、50.0及200.0 mg.kg-1CMCT-Ag+组。测量各组大鼠的牙龈出血指数(BI)、牙菌斑指数(PLI)和牙槽骨吸收值(ABL)。结果:①与正常组比较,模型组牙龈易于出血,牙菌斑数增多,牙槽骨吸收明显;BI、PLI和ABL均高于正常组(P<0.05或P<0.01)。②CMCT-Ag+治疗组与模型组比较:50.0 mg.kg-1组的BI和PLI及200.0 mg.kg-1组BI、PLI和ABL显著低于模型组(P<0.05或P<0.01)。③CMCT-Ag+治疗组与替硝唑组比较:12.5 mg.kg-1组的BI和PLI高于替硝唑组(P<0.01)。④CMCT-Ag+治疗组:12.5 mg.kg-1组BI和PLI高于200.0 mg.kg-1组(P<0.05)。结论:CMCT-Ag+对实验性大鼠牙周炎有明显治疗作用,并随浓度升高治疗作用增强,其中200.0 mg.kg-1CMCT-Ag+对牙周炎大鼠的牙槽骨吸收有一定修复作用。CMCT-Ag+的作用机制主要是抑制牙周组织中的细菌,防止牙菌斑的形成。 Objective To investigate the therapeutic effect of silver carboxymethyl chitosan(CMCT-Ag^+)on experimental periodontitis in rats and the therapeutic mechanism,and provide evidence for preparing drug of treatment for periodontitis with high bactericidal action.Methods The first molar on the right of upper jaw in rats was bound with steel-wire.The gums of rats were spread with Porphyromonas gingivalis and the rats were fed with food of high density of glucose to induce rat periodontitis model.The rats were divided into six groups:control,model,Tinidazole,12.5,50.0 and 200.0 mg·kg^-1 CMCT-Ag^+.Then the bleeding index(BI),plaque index(PLI) and alveolar bone loss(ABL) in rats were observed.Results ① Compared with control rats,the model rats were easier gum blooding,dental plaque number increasing and conspicuous alveolar bone losing.The BI,PLI and ABL in model group were higher than those in control group(P〈0.05 or P〈0.01).② Compared with model group,the BI and PLI in 50.0 mg·kg^-1 CMCT-Ag^+ group as well as BI,PLI and ABL in 200.0 mg·kg^-1 CMCT-Ag^+ group were lower than those in model group(P〈0.05 or P〈0.01).③ Compared with Tinidazole group,the BI and PLI in 12.5 mg·kg^-1 CMCT-Ag^+ group were higher than those in Tinidazole group(P〈0.01).④ Compared between CMCT-Ag+ treatment groups,the BI and PLI in 12.5 mg·kg^-1 group were higher than those in 200.0 mg·kg^-1 group(P〈0.05).Conclusion CMCT-Ag^+ can effectively treat rat periodontitis in a dose-dependent manner and 200.0 mg·kg^-1 CMCT-Ag^+ can repair alveolar bone loss in periodontitis rats.The mechanism that CMCT-Ag^+ can treat rat periodontitis is due to inhibiting bacteria in periodontal tissue and preventing dental plaque from forming.
出处 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2009年第4期669-672,共4页 Journal of Jilin University:Medicine Edition
基金 吉林省科技厅科技发展计划重点项目资助课题(20050413) 吉林省长春市科技计划项目资助课题(08QT10)
关键词 羧甲基壳聚糖银 牙周炎 牙龈卟啉菌 carboxymethyl chitosan-Ag+ periodontitis Porphyromonas gingivalis
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