降糖安脉胶囊治疗Ⅱ型糖尿病的实验研究

Experimental Studies of Non - insulin Dependent Diabetes Medllitus Treated with Jiangtang Anmai Capsule

本实验用1％STZ溶液注射于大鼠腹腔内,造成糖尿病动物模型,观察降糖安脉胶囊的治疗作用。结果表明:该方药可显著降低STZ模型大鼠的空腹血糖;改善坐骨神经的传导功能;显著降低红细胞山梨醇含量;改善血液流变性和坐骨神经内微血管状态。提示降糖安脉胶囊可通过修复损伤的胰岛β细胞、促进胰岛素分泌、改善血液流变性和微循环、增加周围神经组织的血液供应和营养、抑制醛糖还原酶活性、阻断多元醇代谢通路等多种途径,实现对Ⅱ型糖尿病的治疗作用。

Application of 1 % STZ solution intraperitoneal injection to replicate rat diabetes medllitus model, and to observe the effect of Jiangtang Anmai Capsule (JTAMC). The results showed: JTAMC can markedly decrease the content of fasting blood - glucose of model rat, improve conduction fuction of sciatic nerve, significantly decrease the content of erythrocyte sorbite, improve the blood rheological property and micro vessel state in sciatic nerve. It indicated that JTAMC has therapeutic effect on non - insulin dependent diabetes medllitus through repairing the injured islet beta cell, improving insulin secreting and blood rheological property, in creasing the blood supply and nutrition in peripheral nerve tissue, inhibiting the activity of aldose reductase, blocking polybasic alcohol metabolism.