黄藤素静脉滴注致唾液腺肿大

Salivary gland swelling following an intravenous infusion of fibrauretin

1例35岁女性患者,因患急性盆腔炎,给予甲硝唑注射液0.5 g静滴;黄藤素注射液80 mg+5%葡萄糖注射液500 ml静滴。静滴黄藤素至约200 ml患者出现舌体麻木、唾液腺肿大,伴发热,T38.2℃。立即停用黄藤素注射液,给予地塞米松10 mg静滴,苯海拉明20 mg肌注。30 min后症状逐渐缓解,次日唾液腺肿大基本消失。之后患者用头孢噻肟和甲硝唑治疗,未再发生上述症状。

A 35-year-old woman with acute pulvic inflammation received an IV infusion of metronidazole 0.5 g, followed by an IV infusion of fibrauretin 80 mg in 500 ml of glucose 5%. The patient developed tongue numbness, salivary gland swelling, and a fever of 38.2℃ while receiving about 200 ml of fibrauretin infusion. Fibrauretin was stopped immediately. An IV infusion of dexamethasone 10 mg and IM diphenhydramine 20 mg were given. Thirty minutes later, his symptoms gradually relieved. The next day, salivary gland swelling disappeared basically. Subsequently, the patient received cefotaxime and metronidazole, and the above-mentioned symptoms did not recur.