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可用于白酒的复配功能成分对小鼠酒精性肝损伤保护作用的研究

Study on the Protective Effects of the Complex Functional Components Suitable for Liquor on Alcoholic Liver Damage in Mice
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摘要 复制小鼠酒精性肝损伤模型,以评价可用于白酒的复配功能成分(CFCSL)是否能够减轻酒精对肝脏的损伤。小鼠预先给予含不同CFCSL剂量的白酒样品后,一次性灌服大量酒精以造成肝损伤,取小鼠血清,测定丙氨酸转氨酶(ALT)和天门冬氨酸转氨酶(AST)活力;取小鼠肝脏,测定丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-PX)活力和甘油三酯(TG)含量,并作病理组织形态学检验。结果表明,高剂量的CFCSL给药组小鼠血清ALT、AST活性的升高显著低于模型对照组(p<0.05);高、中剂量的CFCSL给药组小鼠肝脏MDA含量的升高和GSH-PX活力的降低较模型对照组有显著的差异(p<0.01,p<0.05);低剂量的CFCSL给药组小鼠血清和肝脏相关指标的改变无统计学意义;各给药组小鼠肝脏TG含量的增加和组织形态学改变较模型对照组有一定的改善。可用于白酒的复配功能成分对酒精引起的肝损伤有显著的保护功能,且作用与剂量相关。 The model of alcoholic liver damage in mice was duplicated to evaluate the protective effects of the complex functional components suitable for liquor (CFCSL) on liver. In the experiments, mice were administered liquor samples containing different CFCSL dosage beforehand and then filled with large amount of alcohol at a time to induce liver damage, then the alanine aminotransferase (ALT) and aspartate aminotransferase(AST) of blood serum and the malonaldehyde(MDA), glutathion peroxidase(GSH-PX) and triglycerides(TG) of liver were measured and histopathological tests were carried out.The results showed that the activity of ALT and AST in serum of mice with high CFCSL dosage treatment were significantly lower than that ofmodle group (p〈0.05), there was significant difference (p〈0.05, p〈0.01) in MDA content and GSH-PX activity between the group of mice with high/medium CFCSL dosage treatment and model group, the change of related indexes in serum and liver in mice with low CFCSL dosage treatment was of no statistical significance, and TG content increment and histological change in liver in mice of each group got improved compared with model group. In conclusion, CFCSL had evident protective effects on liver damage induced by alcohol and such effects were closely related to CFCSL dosage.
出处 《酿酒科技》 2009年第9期44-47,共4页 Liquor-Making Science & Technology
关键词 复配功能成分 酒精性肝损伤 小鼠 转氨酶 病理组织形态学 complex functional components alcoholic liver damage mice aminotransferase histopathology
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