摘要
目的探讨CD44mRNA在非小细胞肺癌(NSCLC)组织中的表达情况及其临床预后的关系。方法应用RT-PCR方法检测36例NSCLC组织和10例正常肺组织中CD44mRNA的表达,并对36例NSCLC患者进行5年以上随访。结果①36例NSCLC组织有21例CD44mRNA的过量表达,过量表达率为58.3%。②CD44 mRNA在NSCLC组织中的表达与病人的年龄、性别、组织学类型、TNM分期、肿瘤大小无关,只与淋巴结转移有相关(P=0.007)。③经Kaplan-Meier生存曲线分析表明,36例NSCLC组织中CD44过量表达组生存率低于一般表达组(P=0.001)。结论CD44mRNA过量表达的NSCLC患者淋巴结转移率高,CD 44mRNA的表达对患者的预后和术后放疗及化疗具有指导性作用。
Objective To determine the expression of CD44 mRNA in non-small cell lung cancer （NSCLC） tissues and the relationship of prognosis. Methods The expression of CD44 mRNA in 36 specimens of NSCLC tissues and 10 normal lung tissues and were determined by RT-PCR and follows up the survival of the 36 patients for more than 5 years. Results （1） CD44 mRNA were excessively expressed in 21 of 36 specimens of NSCLC tissues,excessive expression rate is 58.3% .（2） The expression of CD44 mRNA in NSCLC tissues is related to metastasis of lymph node（ P = 0. 007）, not related to age, sex, histological types, TNM stages, tumor size of the patients. （3） Kaplan-Meier survival curve shows that survival rate of CD44-positive is lower than CIMd-negative in 36 specimens of NSCLC tissues （ P = 0. 001 ）. Conclusion The lymph node is easily metastasized in NSCLC that CD44 mRNA excessive expressed. CD44 mRNA expression guides the prognosis and the radiotherapy and chemotherapy of post-operation.
出处
《中国实验诊断学》
北大核心
2009年第9期1161-1163,共3页
Chinese Journal of Laboratory Diagnosis
