异种表面角膜镜片术

An experimental and clinical study on heteroepikeratophakia

目的介绍异种表面角膜镜片术（ＨＥＰ）的动物实验和临床应用。方法异种（人给猴）表面角膜镜片术（ＥＫＰ）动物实验进行了８例，术后不同时间进行了组织病理学检查。临床上给４例圆锥角膜和９例无晶体眼进行了异种（猴→人）ＥＫＰ术。结果８例实验动物有７例异种表面角膜镜片获得透明，术后镜片上皮化４～６ｄ完成，基质内角膜细胞再分布一般在９个月完成，观察时间６～２４个月。９例无晶体眼７例成功，４例圆锥角膜全部成功，观察时间５～３２个月，视力均有提高。

ObjectiveTo present the effect of heteroepikeratophakia (HEP) on animal and clinical cases.Methods8 cases of HEPs to monkey were performed in the animal examination with light microscope and electron microscope after operation.4 HEPs for keratoconus and 9 HEPs for aphakia were performed in our clinical study.Results8 HEPs experimental animals got transparent lenticules within a follow up time of 6～24 mon.The lenticules were reepithelized in 4～6 d after operation.Repopulation of the keratocytes in the lenticules was accomplished generally in 9 mon after operation.In the clinical study,all 4 HEPs for keratoconus and 7 of 9 HEPs for aphakia succeeded within a follow up time of 5～32 mon.The visual acuity of all these cases improved.ConclusionHEPs may become a modified operation for kerotoconus and aphakia.