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神经节苷脂治疗婴幼儿大脑性瘫痪临床研究 被引量:1

Clinical study of gangliosides treatment in infant with cerebral palsy
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摘要 目的:探讨神经节苷脂治疗婴幼儿大脑性瘫痪(脑瘫)的临床疗效。方法:将84例脑瘫患儿随机分为治疗组和对照组,各42例。两组性别、年龄、临床分型、伴随疾病、头颅CT及发病因素等对比差异均无显著意义(P〉0.05)。两组均采用支持、对症、脱水和降颅压等常规治疗,并予以物理疗法、针灸、按摩、高压氧等综合治疗,治疗组患儿同时加用神经节苷脂2ml(20mg),加入5%葡萄糖注射液250m1中静脉滴注,每日1次,10d为1个疗程。停药20d后进入下一个疗程,连续治疗6个疗程。结果:与对照组相比,洽疗组治疗后发育商评分明显上升,头颅CT阳性率显著降低。治疗组总有效率为95%(40/42)与对照组的79%(33/42)相比差异有显著意义(P〈0.05)。结论:神经节苷脂治疗婴幼儿脑瘫的临床疗效确切。 Objective:To explore the clinical curative effect of gangliosides in infants with cerebral palsy(CP) Methods: Patients with CP (n= 84) were randomly divided into the control group (n= 42) and the treatment group (n= 42). Sexuality,age, clinical classification, accomplished diseases, and brain CT, and other risk factors in two groups had no significant difference(P〉 0.05). Both groups support the use, symptoms, dehydration and lower intracranial pressure, and other conventional treatment, and physical therapy, acupuncture, massage, hyperbaric oxygen therapy, etc. At the same time, the treatment group was added gangliosides 2 ml (20 mg) plus 5% GS 250 ml intravenous drips, qd, 10 for a course of treatment. The next course of treatment, began on the 20th day after a break,which lasted 6 months. Results: As compared with the contral group, the theatment group had an obvious increase in development quotient (DQ),and their positive rate of brain CT decreased obviously. There was significont correlation between the two groups in the fotal effectivehess. Conclusion: The gangliosides treatment of CP of infant clinical curative effect is accurate.
作者 卢国君 王永
出处 《临床神经电生理学杂志》 2009年第5期297-299,共3页 Journal of Clinical Electroneurophysiology
关键词 大脑性瘫痪 婴幼儿 神经节苷脂 发育商 Cerebral palsy Infant Gangliosides Develop nent quotient
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