单味中药金钱草、石韦、车前子对肾结石模型大鼠的预防作用

Inhibition Effect of Chinese Traditional Medicine Lysimachina Christina、Pyrrosia and Plantago on Urinary Calcium Oxalate Stone Formation in Rats

目的:观察单味中药金钱草、石韦、车前子对肾结石的预防作用。方法:90只大鼠随机分为5组,采用1.25%乙二醇和1%氯化铵制备大鼠肾结石模型,用上述3种单味中药的免煎剂型分别给各实验组大鼠肾结石模型灌胃,对照组用枸橼酸钾,4周后观察尿和肾组织中草酸钙结晶的形成情况。结果:单味中药金钱草组、石韦组、车前子组大鼠肾内草酸钙结晶明显少于模型组,而与西药枸橼酸钾组相当。金钱草组、石韦组、车前子组大鼠尿中草酸钙结晶的排泄均明显多于模型组。结论:单味中药金钱草、石韦、车前子对预防大鼠肾结石的形成有确切效果,并与西药枸橼酸钾相当,其作用可能主要是通过增加尿中草酸钙结晶的排泄而达到的。

Objective： To study the inhibition effect of Chinese Traditional Medicine Lysimachina christina, Pyrrosia and plantagoon urinary calcium oxalate stone formation in rats. Methods： 90 healthy male SD rats were randomly divided into five groups, 1.25 % ethylene glycol and 1% ammonium chloride were adopted to make the model of rat oxalate renal stones for each group. Rats in testing groups were given three kinds of single Chinese Traditional Medicine： Lysimachina christina ,Pyrrosia and plan： tago respectively, and rats in the positive control group were given tri - potassium citrate. All rats were fed for 4 weeks. Then we observed calcium oxalate stone formation in rats urine and bilateral kidney. Results：The calcium oxalate stone formation in rats bilateral kidney of Chinese Traditional Medicine groups was obviously lower than that in the model group, but equaled that in tri-potassium citrate group. The calcium oxalate stone formation in rats urine of Chinese Traditional Medicine groups was obviously excessive than that in the model group. Conclusion：Chinese Traditional Medicine Lysimachina christina ,Pyrrosia and plantago can obviously inhibit the formation of the kidney calcium oxalate stone in rats, and the effect equals that in tri - potassium citrate group. Moreover, it may be achieved by increasing the excreting of calcium oxalate stone in rats urine.