Meta分析中的异质性及其处理方法

Discussing on the Research of Heterogeneity in Meta-analysis

介绍Meta分析中异质性研究,包括Meta分析中异质性的定义,并将异质性分为临床异质性、方法学异质性、统计学异质性三类,介绍减少纳入临床异质性和方法学异质性研究的措施,统计学异质性的五种检验方法(Q统计量、I2统计量、H统计量、Galbraith图法、L’Abbe图)、实例分析及适用情况。根据异质性的有无将Meta分析分为探索型Meta分析和分析型Meta分析,存在异质性时可采取的措施及其流程图。

This paper is to discuss the research of heterogeneity in Meta-analysis, including the definition of the heterogeneity in Meta-analysis and classification it into clinical heterogeneity, methodological heterogeneity and statistical heterogeneity, the strategies for diminishing clinical heterogeneity and methodological heterogeneity, the five testing methods in statistical heterogeneity （Q statistic,I^2 statistic, H statistic, Galbraith plot and L＇Abbe plot） and the examples and applying conditions of the five testing methods, classification of meta-analysis into exploratory meta-analysis and analytic meta-analysis according if the meta-analysis has heterogeneity, and the strategies and the flowchart when existing the heterogeneity in meta-analysis.