摘要
目的探讨副脊索瘤临床病理学特点及其诊断与鉴别诊断。方法对报道的3例副脊索瘤进行临床资料分析、组织学形态和免疫表型观察并复习相关文献。结果副脊索瘤好发于四肢深部软组织。大体呈分叶状或多结节状,瘤细胞圆形或多边形,呈条索状或小巢状排列,胞质内含有空泡,间质富有黏液基质。免疫组化标记:CAM 5.2、EMA、S-100、SMA、ColⅣ阳性表达,CEA、CK19、Des阴性。结论副脊索瘤是一种少见的软组织肿瘤,组织学形态特点是其诊断的主要依据,免疫组化标记有助于诊断和鉴别。
Purpose To investigate the clinicopathological feature,diagnosis and differential diagnosis of parachordoma.Methods Three cases of parachordoma were studied by clinical data analyses,histopathology and immunohistochemistry.The related literature were reviewed.Results The tumors mainly occurred in the deep soft tissue of the limbs.Tumor was lobulated or multinodular.The neoplastic cells were round or polygon with vacuoles within the cytoplasma which arranged in nests or cords,and the stroma was rich in myxoid matrix.Immunohistochemically,the tumor cells were positive for CAM 5.2,EMA,S-100,SMA,collagen Ⅳ,and negative for CEA,CK19 and desmin.Conclusions Parachordoma is a rare soft tissue tumor,and its diagnosis mainly depends on histopathologic feature.Immunohistochemistry is helpful for the diagnosis and differential diagnosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2009年第5期491-493,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
副脊索瘤
诊断
鉴别诊断
免疫组织化学
parachordoma
diagnosis
differential diagnosis
immunohistochemistry