酒精性肝病的血清蛋白电泳分析

Changes of Serum Protein Electrophoresis in Alcoholic Liver Disease

目的探讨酒精性肝病患者的血清蛋白电泳变化及其在诊断中的临床价值。方法采用法国SEBIA全自动电泳仪琼脂糖电泳系统检测166例临床确诊的酒精性肝病患者和120例健康体检者的血清蛋白电泳图谱。结果166例酒精性肝病患者与对照组血清蛋白电泳组分的比较,酒精性脂肪肝组各种蛋白成分与对照组差异无统计学意义,而酒精性肝炎组白蛋白、α2球蛋白和γ球蛋白差异有统计学意义(P<0.05),α1球蛋白和β球蛋白差异无统计学意义(P>0.05);酒精性肝纤维化及硬化组白蛋白、α2球蛋白、β球蛋白和γ球蛋白差异有统计学意义(P<0.05),α1球蛋白差异无统计学意义(P>0.05)。结论血清蛋白电泳对于酒精性肝病的诊断有重要的临床价值。

Objective To analyze the results of serum protein electrophoresis and its clinical diagnosis significance in patients with alcoholic liver disease. Methods The SEBIA agarose gel electrophoresis technique was used for serum proteinelectrophoresis, albumin, a1, a2, β and ）,in globin were determined in 166 alcoholic liver disease patients and 120 healthy controls. Results No statistically significant difference was found in the percentages of all proteins between alcoholic fatty liver group and control group. There were statistically significant differences in the percentages of albumin, α2, and γ globin between alcoholic hepatitis group and control group （P〈 0.05）, but the difference was not statistically significant in the percentages of α1 and β globin （P 〉 0.05）. There were statistically significant differences in the percentages of albumin, α2., β and γ globin between alcoholic liver fibrosis group and alcoholic liver cirrhosis group （P〈0.05）, but no statistically significant difference was found in the percentage of α1 globin （P 〉 0.05） . Conclusions The changes in serum protein electrophoresis can comprehensively present the protein change in liver disease cases and work as valuable index of diagnosis, therapy and observation of liver disease.