摘要
目的比较和观察洛伐他汀单独或与银丹心脑通软胶囊联合使用对原发性高血压患者颈动脉内膜中层厚度(CAIMT)及血脂相关危险因素的影响和临床意义。方法135例Ⅰ、Ⅱ级高血压且血脂正常患者被随机分为两组,A组应用洛伐他汀10mg,每日1次,治疗12周;B组除应用洛伐他汀10mg(每日1次)外,联合应用银丹心脑通软胶囊每次3粒(0.4g/粒),每日3次,治疗12周。治疗前、后超声检测CAIMT,酶法测定患者血清中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)。结果相对于治疗前,治疗后4周血压显著下降(P<0.05),12周后血压趋于稳定,两组的降压幅度差异无统计学意义(P>0.05);与治疗前相比,A组患者CAIMT显著降低(P<0.05),TC、LDL-C、TG、HDL-C无显著改变(P>0.05);B组TC、LDL-C、TG、CAIMT均显著降低(P<0.01),且HDL-C明显升高(P<0.01);两组TC、LDL-C、TG比较差异有统计学意义(P<0.05),HDL-C比较差异也有统计学意义(P<0.01)。结论银丹心脑通软胶囊联合洛伐他汀联合应用与单独使用比较,能有效改善原发性高血压患者CAIMT,其作用机制可能与降低血浆中TC、TG、LDL-C和升高HDL-C含量有关。
Objective To compare and observe the effect of lovastatin alone and combination with Yingdan Xinnaotang Soft Cap sule on carotid artery intercellular membrane thickness (CAIMT) and blood fat related risk factors in 135 patients with essential hypertension and to investigate the clinical significance. Methods 135 patients with mild to moderate essential hypertension and normal lipidemia level were randomly divided into 2 groups:group A, 10mg lovastatin was given once a day, group B, 1.2g Yingdan Xinnaotang Soft Capsule (0.4 g / capsulae ) combining with 10 mg lovastatin were given 3 times one day. Both groups were treated for 12 weeks. CAIMT was determined by hypersound examination. Serum TC,TG, LDL-C and HDL-C were measured before and after the treatment. Results After 4-week treatment, blood pressures in both groups decreased significantly compared with pretreatment(P〈0.05). The blood pressures revived to a stable level after 12 weeks. There was no significant difference in decreased amplitude of BP between the two groups(P〈0.05). CAIMT of the patients in group A decreased significantly compared with pretreatment( P〈0.05 ). However,no obvious change was seen in TC,LDL -C,TG and HDL-C in this group(P〉0.05). TC,LDL-C, TG,IMT in group B decreased significantly compared with pretreatment(P〈0.05). Moreover, the HDL-C increased remarkablely (P〈0.01). There were statistical differences in TC,LDL-C,TG and HDL-C(P〈0.05,P〈0.01). Conclusion Yingdan Xinnaotang Soft Capsule combining with lovastatin could effectively improve CAIMT of the patients with mild to moderate essential hypertension compared with the only use of lovastatin. The mechanism may be related to TC,TG and LDL-C decreasing and HDL-C increasing.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第23期2980-2982,共3页
Chongqing medicine