4-氨基-6氯苯-1,3-二磺酰胺含量的快速测定

Rapid determination of 4-amino-6-chlorobenzene-1-3-disulphonamide

目的改进4-氨基-6氯苯-1,3-二磺酰胺含量测定方法。方法采用紫外分光光度法,于波长261 nm下测定。结果该方法在浓度1.00~20.00 g/ml之间有很好的线性关系,相关系数是0.9999,平均回收率100.1%,RSD为0.4%。结论该法简便、快速、准确度和灵敏度高,可作为氢氯噻嗪原料药中间体的质量控制方法。

Aim To improve a method for determining the content of 4-amino-6-chlorobenzene-1-3-disulphonamide.Methods An ultraviole spectrophotometry was used to determine the content at 261nm.Results The method had a good linear at the range of 1.00～20.00 g/ml,with a correlation coefficient of 0.9999.The average recovery rate was 100.1 %,and RSD was 0.50 %.Conclusion The method was easy,quick,accurate,sensitive and can be used to control the quality of hydrochlorothiazide intermediate raw materials.