摘要
目的:研究栀子总苷(TGZ)对幽门结扎模型大鼠胃溃疡的影响,初步探讨其抗溃疡作用的机制。方法:采用大鼠幽门结扎的方法建立大鼠胃溃疡模型,收集胃液测定胃液游离酸和总酸、胃蛋白酶活性以及观察胃黏膜损伤指数。结果:TGZ灌胃70或140mg/kg5d能显著抑制幽门结扎大鼠胃溃疡的发生,抑制胃液量,降低胃液中游离酸度与总酸度,有效降低胃液中胃蛋白酶活性。结论:栀子总苷对幽门结扎所致的大鼠胃溃疡具有明显的保护作用,与其抑制胃酸分泌和胃蛋白酶的活性有关。
AIM:To investigate the antiulcer effect and concerned mechanism of total glycosides of Zhizi(TGZ) in pylorus ligature rats(Shay-rats).METHODS:Pylorus-ligation induced gastric ulceration in rats(Shay-rats model).Quantity determined the free acid,total acid contents and pepsase activity in gastric juice.The effect of TGZ on gastric mucosal lesion index in rats was also determined.RESULTS:TGZ 70 or 140 mg/kg injection gavage for five days versus shay model rats could significantly prevent gastric ulceration decreased free acid,total acid contents and pepsase activity of gastric juice.CONCLUSION:TGZ,through inhibiting gastric acid and pepsase activity evokes its anti-ulceration.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第10期1106-1109,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
栀子总苷
胃溃疡
大鼠
total glycosides of Zhizi
peptic ulcer
rat