急性白血病长期生存相关因素研究

Study on factors associated with long-term survival of acute leukemia

目的分析影响急性白血病（AL）长期生存的因素。方法对143例AL患者中27例生存5年以上患者的临床资料进行回顾性分析，AL患者诱导缓解期采用强烈联合化疗并实行个体化用药原则，坚持缓解后正规的巩固强化治疗，长期随访观察，根据情况调整用药方案。结果143例AL中达到完全缓解112例（78．3％），27例（18．9％）达5年以上长期生存。结论影响AL长期生存的主要因素为AL类型、白血病细胞负荷、髓外白血病、个体化治疗、达到完全缓解的时间、强化治疗的时间、规范的缓解后治疗等。

Objective To analyze factors associated with long-term survival of acute leukemia （AL）. Methods Clinical data is analyzed in 27 leukemia cases who had at least 5 years free survival （EFS）. Combined intensive chemotherapy was administered under the principle of individualization to induce remission. Regular consolidation treatment after remission was strictly continued. Long-term follow up was kept on, with the therapeutic regimen modified accordingly. Results Complete remission （CR） was achieved in 112 of 143（78.3 %） AL patients and 27（18.9 %） of them had survived more than 5 years. Conclusion The long-term survival of AL patients is related to the type of AL, leukemia cell burden, extramedullary leukemia, individual treatment, time required to achieve CR, continuous intensive chemotherapy and the regular postremission treatment.