摘要
目的探讨健脾化瘀方中的药物对消化道肿瘤细胞的体外抑制作用,健脾药物和化瘀解毒药物之间的协同作用。方法采用MTT法,观察不同浓度的健脾化瘀药物对人消化道肿瘤细胞增殖的影响,采用WEB系数法,评价健脾药物和化瘀解毒药物之间的协同作用。结果健脾化瘀方中各药物除黄芪和莪术外,其他各药体外均有一定程度的肿瘤抑制作用;在药物作用48 h后,健脾药物和化瘀解毒药物之间有协同作用。结论健脾化瘀方中药物大多数对消化道肿瘤细胞均有一定程度的抑制作用,健脾法和化瘀解毒法在体外能表现出协同作用。
OBJECTIVE To explore into the in vitro effect of drugs for invigorating the spleen and removing blood stasis on tumor cells in the alimentary tract and the coordinating effect of drugs for invigorating the spleen and drugs for removing blood stasis and toxins. METHOD MTT method was used to observe the effect of the drugs in different concentrations, and WEB coefficient method was used to evaluate the coordinating effeet of the two kinds of drugs. RESULT With the exception of Radix Astragali seu Hedysari and Rhizoma Cureumae, all the other drugs in the prescription had tumor- inhibiting effect, and the coordinating effect occurred 48 hours after drug administration. CONCLUSION Most of the drugs in the prescription for invigorating the spleen and removing blood stasis have inhibiting effect on tumor cells and drugs for invigorating the spleen and drugs for removing blood stasis and toxins assume in vitro coordinating effect.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2010年第1期33-35,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
江苏省科技厅基金项目(BZ2007079)
江苏省中医药局基金项目(LZ09060)
关键词
健脾化瘀药物
消化道肿瘤细胞
协同作用
drugs for invigorating the spleen and removing blood stasis
tumor cells in the alimentary tract
coordinating effect
