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五田保肝液对大鼠酒精性肝病防治作用的研究

WuTianbaoganye's treatment effect on alcohol liver disease in rats
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摘要 目的探讨五田保肝液对大鼠酒精性肝病的防治作用。方法将100只Wistar大鼠随机分成6组:正常对照组10只、模型组、五田保肝液低、中、高剂量组、易善复组各18只,采用白酒辅以吡唑、玉米油的混合食料灌胃的方法建立大鼠酒精性肝病模型,12周末取血用于检测大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性,及甘油三酯(TG)、总胆固醇(TC)的水平,酶联免疫吸附法检测LN和PⅢP的水平;处死大鼠后,HE染色观察肝组织病理改变,Masson染色进一步观察肝组织纤维化情况。结果模型组肝细胞脂肪变性,纤维组织增生,炎性表现明显,大鼠体重增长不明显,肝指数增高,中药治疗各组和易善复组病变较模型组轻,且大鼠体重增加,肝指数下降。五田保肝液和易善复还可降低酒精性肝病大鼠血清ALT、AST、TG、TC、LN、PⅢP的水平,并有一定剂量依赖性。结论五田保肝液对大鼠酒精性肝病具有确切的防治作用,尤以中、高剂量效果显著。 Objective To investigate WuTianbaoganye's treatment effect on alcohol liver disease(ALD) in rats. Methods 100 Wistar rats were assingned at random six groups: a normal group (10), a model control group(18), WuTianbaoganye low dose group(18), middle dose group(18), high dose group(18), Yishanfu group(18). Rat model of ALD was induced by perfusing stomach with the mixture of liquor, pyrazol and corn oil . After 12 weeks intervention, To observation variety of liver tissue pathology and ALT. AST. TG. TC. LN. PⅢP in serum of rats.Results Model group' s rats have significantly higher steatosis, inflammation, liver fibrosis, liver index, lower weight, and increased level ofALT. AST. TG. TC. LN. PⅢP in serum of rats, compared with those of the normal rats. WuTianbaoganye groups and Yishanfu group' s rats have mild pathological changes, higher weight, lower liver index, and decreased level of ALT. AST. TG. TC. LN. PⅢP in serum of rats, compared with those of the model rats. Curative effect is relative with dose. Conclusion WuTianbaoganye had an active effect on inhibiting ALD in rats, especially middle, high dose.
出处 《湖南中医药大学学报》 CAS 2009年第12期34-36,81,共4页 Journal of Hunan University of Chinese Medicine
基金 天津市汉沽区科委课题(HK2008FA017)
关键词 五田保肝液 酒精性肝病 大鼠 WuTianbaoganye alcohol liver disease rat
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