氨溴索对COPD患者血清细胞因子和肺功能的影响

The effect of ambroxol on concentrations of serum cytokine and pulmonary function in patients with chronic obstructive airway disease

目的探讨氨溴索对COPD患者血清细胞因子白介素-8(IL-8)、白介素-10(IL-10)、肿瘤坏死因子-α(TNFα-)水平和肺功能的影响。方法选择80例AECOPD,随机分成氨溴索组40例和对照组40例,比较两组治疗后血清细胞因子IL-8、IL-10、TNFα-水平和肺功能的变化。结果氨溴索组治疗前后血清IL-8、IL-10、TNFα-水平差值显著大于对照组(P<0.01),肺功能1秒钟用力呼气容积占预计值百分比(FEV1%)、1秒钟用力呼气容积/肺活量(FEV1/FVC)差值显著大于对照组(P<0.01)。结论氨溴索能显著降低COPD患者血清炎症细胞因子水平,减轻炎症反应,显著改善通气功能。

Objective To investigate the effect of ambroxol on concentrations of serum cytokine interleukin,-8 （ IL-8 ） , interleukin- 10（IL-10） ,tumor necrosis factor-alpha （TNF-α）and pulmonary function in patients with chronic obstructive airway disease （COPD）. Methods 80 hospitalized patients with COPD at acute exacerbation stage in Nanhui Central Hospital from February 2008 to April 2009 were divided into the ambroxol group（ n = 40） and control group （ n = 40 ）. Concentrations of serum IL-8, IL-10, TNF-α and pulmonary function parameter included the ratio of forced expiratory volume in one second and predicted value（ FEV1 % ） and forced expiratory volume in one second divided by forced vital capacity（FEV1/FVC） were measured in all subjects. Results The difference of value of serum IL-8, IL-10,TNF-α concentrations and FEV1%, FEVI/FVC in the ambroxol group were significantly higher than those in the controls（ P 〈 0. 01）. Conclusion Ambroxol can reduce the concentrations of serum cytokine, relieve inflammatory reaction and improve ventilation function significantly in patients with COPD.