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后程三维适形放疗与羟基喜树碱同步化疗治疗直肠癌脑转移疗效观察

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摘要 目的探讨后程三维适形放疗(3D-CRT)与羟基喜树碱(HCPT)同步化疗治疗直肠癌脑转移的临床疗效。方法将66例直肠癌脑转移患者随机分为观察组和对照组,两组前程治疗均行普通二维放疗,全脑照射总剂量(DT)30—40Gy;后程缩野对脑转移癌局部病灶行3D—CRT,DT50~64Gy。观察组放疗2—4周后静滴HCPT同步化疗。观察两组疗效及不良反应。结果观察组有效率83.3%,对照组56.7%,两组比较有统计学差异(P〈0.05)。观察组白细胞下降、恶心、呕吐发生率高于对照组,两组2a生存率比较有统计学差异(P〈O:05)。结论后程3D-CRT联合HCPT同步化疗治疗直肠癌脑转移近、远期疗效较好,不良反应轻微,患者均能耐受。
出处 《山东医药》 CAS 北大核心 2009年第49期89-90,共2页 Shandong Medical Journal
基金 河北省科学技术成果(20091420)
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