广东顺德原发性肝癌的危险因素与家庭相关性研究

Study on the risk factors and familial correlation of primary hepatocellular carcinoma(PHC) in Shunde,Guangdong

目的探索广东顺德地区肝癌高发的主要危险因素、肝癌发生的家庭相关模式以及HBV感染对肝癌家庭相关的影响。方法20062008年在广东顺德进行原发性肝癌的病例对照家系研究;应用非条件Logistic回归模型估计危险因素与肝癌的关联,父母受累、同胞受累与先证者肝癌关联的OR值描述肝癌的家庭相关。结果在未考虑HBsAg状态时,同胞表型与肝癌的关联OR值为3.34（95%CI：1.149.75）;父母表型与肝癌关联的OR值为0.92（95%CI：0.332.56）。考虑HBsAg状态后,同胞表型和肝癌关联的OR值有所降低,为2.94（95%CI：0.949.25）;HBsAg阳性可增加肝癌的风险,调整的OR值为4.38（95%CI：2.447.87）。结论广东顺德地区HBV感染是原发性肝癌的主要危险因素;肝癌具有家庭聚集性,主要表现为同胞间的相关,且受HBV感染的影响。

Objective To examine the risk factors and familial correlation of primary hepatocellular carcinoma（PHC） and the effect of hepatitis B virus（HBV） infection on familial correlation of PHC in Shunde,Guangdong.Methods A case-control family study of PHC in Shunde,Guangdong,in 2006-2008 was carried out.Logistic regression model was used to estimate the association between risk factors and PHC,and the odds ratios（ORs） for disease status of liver cancer for parents and siblings associated with that of the probands were used to assess the familial correlation of liver cancer.Results Siblings affected with PHC was significantly associated with PHC status of the probands without taking into account HBV infection,with the OR of 3.34（95%CI,1.149.75）.The OR for affected with PHC for parents associated with PHC status for the proband,was 0.92（95%CI,0.332.56）.The OR of siblings affected with PHC was 2.94（95%CI,0.949.25） after taking HBV infection into account.HBV infection was likely to increase the risk of PHC and the adjusted OR was 4.38（95%CI,2.44 7.87）.Conclusion HBV infection was likely a main reason for high prevalence of PHC in Shunde,Guangdong.PHC showed familial aggregation.The correlation between siblings was significant and was influenced by the HBV infection.