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细胞凋亡和白血病的治疗 被引量:2

Cell Apoptosis and Treatment of Leukemia
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摘要 细胞凋亡是多细胞生物体的重要自稳机制之一,它的异常在白血病发病学上具有重要作用。相应地,干预细胞凋亡的手段可望成为白血病治疗的新策略。这些手段至少包括:①下调Bcl-X_L等凋亡抑制基因或上调Bax等凋亡诱导基因的表达,改变肿瘤细胞凋亡的阈值;②Fas及肿瘤坏死因子等相关物的应用;③凋亡诱导物(如三氧化二砷)的开发,等等。 Cell apoptosis is one of the most important self -stabilization mechanism for multi - cellular organism, itsdisnormality is important for etiology of leukemia. So,methods intervening cell apoptosis may become new thera-peutic strategy for leukemia. These methods at least in-clude: a) changing threshold of tumor cell apoptosis, bydown - regulating translation of apoptosis - inhibiting genesuch as Bcl - XL, or up - regulating translation of apopto-sis - inducing gene such as Bax; b) application of Fas, tu-mor necrosis factof, and other relative factors; c) exploita-tion of apoptosis - inducing factors, such as arsenic triox-ide, etc.
作者 陈国强 陈竺
出处 《引进国外医药技术与设备》 1998年第4期17-22,16,共6页
关键词 细胞凋亡 白血病 治疗策略 cell apoptosis leukemia treatment
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同被引文献23

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