摘要
细胞凋亡是多细胞生物体的重要自稳机制之一,它的异常在白血病发病学上具有重要作用。相应地,干预细胞凋亡的手段可望成为白血病治疗的新策略。这些手段至少包括:①下调Bcl-X_L等凋亡抑制基因或上调Bax等凋亡诱导基因的表达,改变肿瘤细胞凋亡的阈值;②Fas及肿瘤坏死因子等相关物的应用;③凋亡诱导物(如三氧化二砷)的开发,等等。
Cell apoptosis is one of the most important self -stabilization mechanism for multi - cellular organism, itsdisnormality is important for etiology of leukemia. So,methods intervening cell apoptosis may become new thera-peutic strategy for leukemia. These methods at least in-clude: a) changing threshold of tumor cell apoptosis, bydown - regulating translation of apoptosis - inhibiting genesuch as Bcl - XL, or up - regulating translation of apopto-sis - inducing gene such as Bax; b) application of Fas, tu-mor necrosis factof, and other relative factors; c) exploita-tion of apoptosis - inducing factors, such as arsenic triox-ide, etc.